Group 25 Presentation
Darya Trubach, Emilie Sofie Engdal, Manon Kirstine Chevalier
Introduction
Biological background
Methods
Barracoda data - Table 1a
| AP (N=13465) |
BS (N=7840) |
BC (N=10491) |
Overall (N=31796) |
|
|---|---|---|---|---|
| KIR_blocking | ||||
| 1 | 7541 (56.0%) | 4019 (51.3%) | 7877 (75.1%) | 19437 (61.1%) |
| 0 | 5924 (44.0%) | 3821 (48.7%) | 2614 (24.9%) | 12359 (38.9%) |
| log_fold_change | ||||
| Mean (SD) | -1.15 (3.29) | -2.25 (3.95) | -1.49 (3.69) | -1.53 (3.62) |
| Median [Min, Max] | -0.182 [-13.4, 9.71] | -0.508 [-12.0, 8.64] | -0.313 [-12.4, 11.2] | -0.290 [-13.4, 11.2] |
| protein | ||||
| ORF1 | 7239 (53.8%) | 4447 (56.7%) | 6103 (58.2%) | 17789 (55.9%) |
| Nucleocapsid | 707 (5.3%) | 434 (5.5%) | 548 (5.2%) | 1689 (5.3%) |
| Spike | 2619 (19.5%) | 1581 (20.2%) | 2062 (19.7%) | 6262 (19.7%) |
| ORF6 | 68 (0.5%) | 42 (0.5%) | 65 (0.6%) | 175 (0.6%) |
| Membrane | 785 (5.8%) | 465 (5.9%) | 545 (5.2%) | 1795 (5.6%) |
| ORF3 | 540 (4.0%) | 345 (4.4%) | 467 (4.5%) | 1352 (4.3%) |
| ORF7 | 288 (2.1%) | 175 (2.2%) | 227 (2.2%) | 690 (2.2%) |
| Envelope | 119 (0.9%) | 73 (0.9%) | 91 (0.9%) | 283 (0.9%) |
| ORF10 | 119 (0.9%) | 73 (0.9%) | 91 (0.9%) | 283 (0.9%) |
| ORF8 | 322 (2.4%) | 205 (2.6%) | 292 (2.8%) | 819 (2.6%) |
| Unknown | 659 (4.9%) | 0 (0%) | 0 (0%) | 659 (2.1%) |
| HLA | ||||
| HLA-C04:01 | 300 (2.2%) | 600 (7.7%) | 2400 (22.9%) | 3300 (10.4%) |
| HLA-C06:02 | 2695 (20.0%) | 1086 (13.9%) | 1164 (11.1%) | 4945 (15.6%) |
| HLA-C07:01 | 4014 (29.8%) | 2950 (37.6%) | 2655 (25.3%) | 9619 (30.3%) |
| HLA-C07:02 | 6456 (47.9%) | 3204 (40.9%) | 4272 (40.7%) | 13932 (43.8%) |
Flowjo data - Table 1b
| KIR-blocked (N=30) |
Not KIR-blocked (N=26) |
Overall (N=56) |
|
|---|---|---|---|
| APC_positive | |||
| Mean (SD) | 0.682 (0.626) | 1.43 (2.58) | 1.03 (1.84) |
| Median [Min, Max] | 0.450 [0, 2.20] | 0.305 [0, 9.19] | 0.360 [0, 9.19] |
| DP_positive | |||
| Mean (SD) | 0.210 (0.376) | 0.0319 (0.0905) | 0.128 (0.294) |
| Median [Min, Max] | 0.0510 [0, 1.61] | 0 [0, 0.350] | 0.0105 [0, 1.61] |
| PE_positive | |||
| Mean (SD) | 2.86 (3.18) | 6.32 (9.09) | 4.46 (6.78) |
| Median [Min, Max] | 2.18 [0.100, 17.2] | 3.24 [0.160, 46.1] | 2.44 [0.100, 46.1] |
Computations
Results
Visualisation #1
A nice image.
Visualisation #2
Visualisation #3
Discussion
Insert some conclusions here
Questions?
R4BDS